Publications & Presentations

  • Publications
  • Review Articles

Interested to read more about the origins and progress of Alkahest Science? The following are selected peer-reviewed publications with Alkahest scientists and founders.

Undulating changes in human plasma proteome profiles across the lifespan

Lehallier B, Gate D, Schaum N, Nanasi T, Eun Lee S, Yousef H, Moran Losada P, Berdnik D, Keller A, Verghese J, Sathyan S, Franceschi C, Milman S, Barzilai N, Wyss-Coray T.
Nature Medicine. 25, 1843–1850 (2019). doi: https://doi.org/10.1038/s41591-019-0673-2

To help aging populations, classify organismal senescence

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming AG, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, Pedro de Magalhães J, Campisi J, Church G.
Science. 366 (6465), 576-578. doi: 10.1126/science.aay7319

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial

Sha SJ, Deutsch GK, Tian L, Richardson K, Coburn M, Gaudioso JL, Marcal T, Solomon E, Boumis A, Bet A, Mennes M, van Oort E, Beckmann CF, Braithwaite SP, Jackson S, Nikolich K, Stephens D, Kerchner GA, Wyss-Coray T.
JAMA Neurol. 2019 Jan 1;76(1):35-40. doi: 10.1001/jamaneurol.2018.3288.

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T.
JAMA Neurol. 2016 Nov 1;73(11):1325-1333. doi: 10.1001/jamaneurol.2016.3185.

Network-driven Plasma Proteomics Expose Molecular Changes in the Alzheimer’s Brain

Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T.
Mol Neurodegener. 2016 Apr 26;11:31. doi: 10.1186/s13024-016-0095-2. 

β2-microglobulin is a Systemic Pro-aging Factor that Impairs Cognitive Function and Neurogenesis

Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, Gontier G, Wabl R, Plambeck KE, Udeochu J, Wheatley EG, Bouchard J, Eggel A, Narasimha R, Grant JL, Luo J, Wyss-Coray T, Villeda SA.
Nat Med. 2015 Aug;21(8):932-7. doi: 10.1038/nm.3898. Epub 2015 Jul 6.

Young Blood Reverses Age-related Impairments in Cognitive Function and Synaptic Plasticity in Mice

Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T.
Nat Med. 2014 Jun;20(6):659-63. doi: 10.1038/nm.3569. Epub 2014 May 4.

The Ageing Systemic Milieu Negatively Regulates Neurogenesis and Cognitive Function

Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T.
Nature. 2011 Aug 31;477(7362):90-4. doi: 10.1038/nature10357.

Recent and Upcoming Meetings:

Past Talks and Presentations:

Angiogenesis, Exudation, and Degeneration 2020

Miami, FL, February 8, 2020

2nd Annual Longevity Therapeutics

San Francisco, CA, January 28-30, 2020

World Economic Forum Annual Meeting

Davos-Klosters, Switzerland, January 21-24, 2020

12th Clinical Trials on Alzheimer’s Disease

San Diego, CA, December 4-7, 2019

American Academy of Ophthalmology Annual Meeting 2019

New York, NY, October 12-15, 2019

Society for Neuroscience Annual Meeting

Chicago, IL, Oct 19-23 2019

International Congress of Parkinson’s Disease and Movement Disorders

Nice, France, September 22-26, 2019

American Society of Retina Specialists

Chicago, IL, July 26-31, 2019

Ophthalmology Innovation Summit

Chicago, IL, July 25, 2019

Alzheimer’s Association International Conference

Los Angeles, July 14-18, 2019

American Aging Association Annual Meeting

Burlingame, CA, May 29 – June 2, 2019

Aging & Healthspan

San Franciso, May 30, 2019

BioEquity Europe

Barcelona, May 20-21, 2019

Neuroimmunology Drug Development Summit

Boston, April 17-18, 2019

Undoing Aging

Berlin,  March 28-30, 2019

International Conference on Alzheimer’s & Parkinson’s Disease (AD/PD)

Barcelona, March 26-31, 2019

Retina World Congress (RWC)

Fort Lauderdale, March 21-24, 2019

Alzheimer’s Drug Discovery Foundation: Drug Discovery for Neurodegeneration Conference 2019
Interventions in Aging Conference 2019
Longevity Therapeutics Summit 2019
World CNS Summit 2019
Alzheimer’s Association International Conference (AAIC) 2018
Clinical Trials on Alzheimer’s Disease (CTAD) 2018
Society for Neuroscience (SFN) 2018

Inquire if interested in past presentations.