Proteomic exploration has been key to the discovery that our plasma proteome changes with age and disease. We use advanced techniques to find, characterize, and understand chronokines and their biological function. Our arrays, mass spectrometry, mechanistic mapping, and preclinical validation experiments help us isolate chronokines which play a function in the body’s communicome, regulating protein processing, the immune system, and degeneration and regeneration, reactivation of stem cell activity, in the body.
Our proteomic work helps us narrow down on the chronokines which both change significantly with age and disease, and those that serve central checkpoint functions in the biology of aging. The most impactful targets become the inspiration for our therapeutic candidates. We also utilize proteomics to explore plasma samples from our clinical trials, in order to better understand mechanism of action as well as search for biomarkers of relevance to the disease and our drugs.